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S. ZHONG1 P. ROBICHAUD1, A. GHAVAMI1, V. BEAUMONT2, R. CACHOPE2

1PsychoGenics, Inc., Paramus, NJ, USA

Huntington’s disease (HD) is a genetically inherited neurodegenerative disorder caused by an expansion of the triplicate CAG repeat in the Huntingtin (HTT) protein. The cortico-striatal loop and MSN neurons in particular are affected in HD1,2. Local field potentials (LFPs), the aggregate electrical activity of a group of neurons, underlie behaviorally relevant neuronal processing and thus may be useful as a key measurement for understanding the neural basis of the HD behavioral phenotype3. Previous reports have detailed an abnormal increase in gamma oscillations in Q175 het during the wake state in the cortex and striatum4. Yet there are no reported deficits in other frequency bands nor an exploration of possible changes in EEG occurring during different sleep states. In the present study, we replicate findings in the low gamma frequency. In addition, we report a decrease of the delta and theta low frequency bands in cortex as well as striatum and a corresponding increase in the coherence between these brain regions in the z_Q175DN het compared to WT. Furthermore, we observe that these changes are present through both REM and non-REM (NREM) sleep states. Animals were recorded longitudinally from 6-10 months and LFPs in cortex and striatum were separated according to sleep/wake states for analysis.