Autoradiography Services

Functional G-Protein-Coupled Receptor (GPCR) Activation Assay (³⁵SGTPγS Binding)

The ³⁵SGTPγS assay allows for the assessment of functional activation of Gi/Go-coupled receptors by measuring bound ³⁵SGTPγS in brain sections using autoradiography.

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Glucose Metabolism [¹⁴C-2-Deoxyglucose (¹⁴C-2-DG)]

¹⁴C-2-Deoxyglucose (¹⁴C-2-DG) Autoradiography – The ¹⁴C-2-DG autoradiographic method can be used for measuring glucose utilization as a function of neurogenic activity. This assay is useful for identifying brain regions activated by specific drug agents, and therefore, can act as a surrogate for functional MRI.

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In Vivo and Ex Vivo Receptor Occupancy

In vivo & ex vivo receptor occupancy (RO) offers a simple yet powerful way to measure compound/target engagement using a selective radioligand and receptor autoradiography.

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